Kevin has more than twenty-five years of experience in the development of specialized hardware and software for biomedical research and experimentation. He has spent the last twenty years participating in developing the various microscope systems, imaging technologies, and image processing and analysis algorithms and software. In particular he was a principal developer of the Digital Imaging Microscope (DIM), and was intimately involved in designing the other instruments, including the Scratch. He is a skilled programmer, especially in the areas of real-time control systems, high-speed computation, image processing, computer graphics and visualization. He has applied these technical skills together with knowledge of fluorescence microscopy, low light level imaging and image restoration to the imaging and analysis of molecular distributions in fixed and living cells. He has worked extensively in the imaging of calcium in living cells, with a recent focus on understanding the role of elementary calcium release events in calcium signaling.